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According to the article on the main page i would have to recommend Topaz DeNoise as a good tool for removing noise. You can take pretty good control over the process, setting noise reduction strenght percentage, reduce blur, retrieve the detail from de-noised parts of the picture. The tool is very good and provides a high level noise reduction effects without loosing the picture quality.
Yes, very nice tool, but I use the ACR noise reduction for first to go lighter with topaz. In high iso photos is for sure the best software I've ever tried !
Neat Image, Noiseware, Topaz and Noise Ninja (in no particular order) are all very solid products. I echo Astelith suggestion on using a RAW converter's built-in noise reduction as a first step.
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