Canon 300 f/4 L IS USM and its big brother Canon 300 f/2.8 L IS USM. Both lenses without lens hood. Click here to enlarge.
Since early 2008, I own the Canon 300 2.8 L IS, that is considered one of the finest Canon lenses ever made. The Canon 300 f/4 is $2800 cheaper, much smaller and lighter: the 2.8 is really worth the price and weight difference? I have tested the two lenses side by side to answer to this question.
In terms of built quality, the two lenses are similar - sturdy and well built - except for weather sealing: the f/2.8 is sealed, while the f/4 has no weather sealing. Without the large hood, the f/2.8 is not much longer, but it is clearly wider, and it is about 1 kg heavier. Both lenses have "2 stops" image stabilization, even though the IS of the 2.8 is slightly more advanced (it can be kept active when the lens is mounted on a tripod, as far as the support is not too stable).
Both have a fast ultrasonic AF motor, with full time manual focus. Without teleconverters, both the f/4 and the f/2.8 are very fast, even though the f/2.8 is a little better. With the 1.4x TC, the f/2.8 has a more marked advantage, and with the 2x TC the difference is huge: on prosumer SLRs the f/4 does not even work in AF with the 2x, and on 1 series SLRs it is extremely slower than the f/2.8 + 2x. Other than that, the f/4 has a two steps focus limiter, while the f/2.8 has a three steps limiter, that gives more choices (and in some situations it can make a big difference).
 
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